Royals vs. Astros Predictions & Picks: Odds, Moneyline, Spread - September 22

Friday's contest that pits the Houston Astros (85-68) versus the Kansas City Royals (51-102) at Minute Maid Park has a projected final score of 5-4 (based on our computer prediction) in favor of the Astros, who is slightly favored in this matchup according to our model. First pitch is at 8:10 PM on September 22.

The Astros will give the nod to Framber Valdez (12-10, 3.20 ERA), who is eyeing win No. 13 on the season, and the Royals will counter with Cole Ragans (6-4, 3.44 ERA).

Royals vs. Astros Game Info & Odds

• When: Friday, September 22, 2023 at 8:10 PM ET
• Where: Minute Maid Park in Houston, Texas
• How to Watch on TV: SportsNet SW
• Live Stream: Watch this game on Fubo!

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Royals vs. Astros Score Prediction

Our pick for this game is Astros 5, Royals 4.

Total Prediction for Royals vs. Astros

• Total Prediction: Over 8.5 runs

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Explore More About This Game

• Royals Injury Report

• Astros vs Royals Betting Trends & Stats

• Astros vs Royals Pitching Matchup

• How to Watch Astros vs Royals

• Astros vs Royals Odds

Royals Performance Insights

• The Royals have played as the underdog in 10 of their past 10 games and have gone 6-4 in those contests.
• In its last 10 matchups with a total posted by oddsmakers, Kansas City and its opponents are 3-7-0 when it comes to hitting the over.
• The Royals have not covered the runline in any of their previous 10 games (two of those games had a runline).
• The Royals have been underdogs in 131 games this season and have come away with the win 43 times (32.8%) in those contests.
• This year, Kansas City has won seven of 27 games when listed as at least +180 or worse on the moneyline.
• The Royals have an implied victory probability of 35.7% according to the moneyline set by oddsmakers for this matchup.
• The offense for Kansas City is No. 26 in MLB play scoring 4.2 runs per game (635 total runs).
• The Royals have pitched to a 5.15 ERA this season, which ranks 28th in baseball.

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Royals Schedule