JOPLIN, Missouri (CNN) -- A tornado flattened buildings, snapped trees and tossed tractor-trailers like toys as it touched down in Joplin, Missouri, on Sunday night, causing an unknown number of deaths and injuries.
"I would say 75% of the town is virtually gone," said Kathy Dennis of the American Red Cross.
The twister was part of a line of severe weather that swept across the Midwest on Sunday, prompting tornado watches and warnings that stretched from Wisconsin to Texas. High winds and possible tornadoes struck Minneapolis and other parts of Minnesota, leaving at least one person dead and injuring nearly two dozen others, police said.
Authorities in Joplin were contending with multiple reports of people trapped, as well as significant structural damage to St. John's Regional Medical Center, which was hit directly by the tornado, city officials said. CNN affiliate KSHB said there were reports of fires throughout the hospital.
One facade of the building made of glass was completely blown out, and authorities were evacuating the medical center, said Ray Foreman, a meteorologist with KODE in Joplin. Makeshift triage centers were being set up in tents outside, witness Bethany Scutti said.
Residents 70 miles away from Joplin in Dade County, Missouri, were finding X-rays from St. John's in their driveways, said Foreman, indicating the size and power of the twister.
Parts of the city were unrecognizable, according to Steve Polley, a storm chaser from Kansas City, Missouri, who described the damage as "complete devastation."
The tornado, which touched down just before 6 p.m. CDT, cut a path of destruction through the heart of the city, hitting heavily populated areas, Foreman said.
"We've had numerous vehicles picked up and thrown into houses," he said.
At least seven overturned tractor-trailers were seen on one stretch of Interstate 44 west of the city, said Michael Ratliff, who has been chasing storms for eight years. Ratliff said the possible tornado was "rain wrapped," making it impossible to see as it tore what he estimated to be a half-mile to three-quarter-mile path of damage.
Officials did not know how many were injured. Witnesses reported seeing some of the wounded being ferried to hospitals in the backs of pickup trucks as first responders struggled to handle the overwhelming destruction.
Lynn Ostot, the spokeswoman for the city of Joplin, confirmed "some fatalities," but did not have an exact number. The Joplin mayor has declared a local disaster, and the Missouri National Guard was activated by Gov. Jay Nixon.
"These storms have caused extensive damage across Missouri, and they continue to pose significant risk to lives and property," Nixon said in a statement. "As a state, we are deploying every agency and resource available to keep Missouri families safe, search for the missing, provide emergency medical care, and begin to recover."
CNN meteorologist Chad Myers warned that the storms were not over for the Midwest.
"You need to have that NOAA radio on tonight everywhere from Wisconsin to Texas and Oklahoma," he said.