Washington (CNN) -- White House mail handlers identified a "suspicious substance" in a letter sent to President Barack Obama the same day one suspected of containing the poison ricin was found in a Senate mailroom, the Secret Service said Wednesday.
Both letters arrived Tuesday at off-site postal facilities set up after the 2001 anthrax attacks and have been sent to laboratories for additional tests, authorities said.
"A letter addressed to the president containing a suspicious substance was received at the remote White House mail screening facility," Secret Service spokesman Brian Leary said. The Secret Service, FBI and Capitol Police are investigating, he said.
Shortly after that announcement, Capitol Police were checking out reports of suspicious packages or letters in two Senate office buildings. The first floor of the Hart Senate Office Building was evacuated shortly before noon.
That news came a day after preliminary tests on a letter sent to the Senate indicated the presence of ricin, a deadly toxin with no known antidote. Further tests on that letter took place Wednesday, the FBI said.
Senate Majority Leader Harry Reid said he was told the envelope was addressed to the office of Sen. Roger Wicker, a conservative Republican from Mississippi. It had a Memphis, Tennessee, postmark and no return address, Senate Sergeant-at-Arms Terrance Gainer wrote in an e-mail to senators and aides.
Congressional and law enforcement sources said the envelope was intercepted Tuesday at the Capitol's off-site mail facility. Coming on the day after the Boston Marathon bombings, the discovery further heightened security concerns at a time when Congress is considering politically volatile legislation to toughen gun laws and reform the immigration system.
"Monday's attack in Boston reminded us that terrorism can still strike anywhere at any time," Senate Republican leader Mitch McConnell said Wednesday. "And as yesterday's news of an attempt to send ricin to the Capitol reminds us, it is as important as ever to take the steps necessary to protect Americans from those who would do us harm."
A laboratory in Maryland confirmed the presence of ricin on the letter addressed to Wicker after initial field tests also indicated the poison was present, according to Gainer. However, the FBI said additional testing was needed because field and preliminary tests produce inconsistent results.
"Only a full analysis performed at an accredited laboratory can determine the presence of a biological agent such as ricin," according to the bureau. "Those tests are in the process of being conducted and generally take from 24 to 48 hours."
In a statement late Tuesday, the U.S. Capitol Police said further tests would be conducted at the Army's biomedical research laboratory at Fort Detrick, Maryland.
Sen. Claire McCaskill, D-Missouri, told reporters after a briefing for lawmakers that a suspect has already been identified in the incident, but a knowledgeable source said no one was in custody Tuesday night.
Wicker has been assigned a protective detail, according to a law enforcement source.
Postal workers started handling mail at a site off Capitol Hill after the 2001 anthrax attacks that targeted then-Majority Leader Tom Daschle, D-Nebraska, and Sen. Patrick Leahy, D-Vermont, among others.
Senators were told Tuesday that the mail facility would be temporarily shut down "to make sure they get everything squared away," McCaskill said Tuesday afternoon.
"The bottom line is, the process we have in place worked," she said, adding that members of Congress will be warning their home-state offices to look out for similar letters.
McConnell, R-Kentucky, also praised the postal workers and law enforcement officers for "preventing this threat before it even reached the Capitol."
"They proved that the proactive measures we put in place do in fact work," he said.
A previous ricin scare hit the Capitol in 2004, when tests identified a letter in a Senate mailroom that served then-Majority Leader Bill Frist's office. The discovery forced 16 employees to go through decontamination procedures, but no one reported any ill effects afterward, Frist said.
Ricin is a highly toxic substance derived from castor beans. As little as 500 micrograms -- an amount the size of the head of a pin -- can kill an adult. There is no specific test for exposure and no antidote once exposed.
It can be produced easily and cheaply, and authorities in several countries have investigated links between suspect extremists and ricin. But experts say it is more effective on individuals than as a weapon of mass destruction.
Ricin was used in the 1978 assassination of Bulgarian dissident Georgi Markov. The author, who had defected nine years earlier, was jabbed by the tip of an umbrella while waiting for a bus in London and died four days later.
Wicker, 61, was first appointed by former Republican Gov. Haley Barbour to the U.S. Senate in December 2007 after the resignation of then-Sen. Trent Lott. He was then elected to the seat in 2008 and won re-election in 2012 to a second term.
Before joining the Senate, he was a U.S. representative in the House from 1995 to 2007. Before that, he served in the Mississippi Senate.
CNN's Tom Cohen, Rachel Streitfeld and Matt Smith contributed to this report.