Promoters say the pop singer will close his Las Vegas Strip show, "The Red Piano," on April 22.
The show made its debut in February 2004 at The Colosseum theater at Caesars Palace. After initially signing on for 75 shows, John's engagement was extended.
The casino says the closing show will be the 241st performance.
The offbeat production blends the singer's top hits with elaborate video montages created by photographer and director David LaChappelle.
A casino spokeswoman said there was no word on a replacement.