Protestes demonstrate against recent U.S. missile strikes on the Pakistani tribal areas.
The attack occurred in the Mir Ali subdivision in the village of Ali Khel, according to local political official Muhammad Nasim Dawar.
The names of the victims have not yet been released. It is also not yet known why the house was targeted.
Six people were injured in Saturday's attack, the fourth suspected U.S. strike on Pakistani soil in November.
Pakistan's Foreign Ministry summoned U.S. Ambassador Anne Patterson on Thursday to lodge a formal protest against another suspected U.S. missile strike on its territory, an act Pakistan Prime Minister Yousaf Raza Gilani called a violation of his nation's sovereignty.
Wednesday's strike in the Bannu region of Pakistan's North West Frontier Province left five dead and seven wounded Wednesday. That attack was further inside Pakistani territory than previous attacks.
Pakistan warns U.S. over missile strike
The U.S. government has not acknowledged hitting targets within Pakistan, an ally in the war on al Qaeda launched after the September 11, 2001, attacks on New York and Washington. However, Pakistan's government has repeatedly complained about the strikes.
Gilani took to the floor of the parliament and renewed his condemnation of the attacks Thursday, but added he thinks they will be controlled when President-elect Barack Obama takes office.
In October, the foreign ministry summoned Patterson to lodge a "strong" protest on continuing missile attacks and said they should be stopped immediately. At the time, a missile strike from a suspected U.S. drone on a compound in South Waziristan killed 20 people.
Pakistan's government said the attacks cost lives and undermine public support for its counterterrorism efforts.
The U.S-led coalition and NATO, based in Afghanistan, have been seeking a way to effectively battle militants who are launching attacks from Pakistan's swath of tribal areas along the border.
They have become frustrated with Islamabad over the years, saying it is not being active enough against militants, a claim Pakistan denies.
The United States is the only country operating in the region known to have the capability to launch missiles from drones, which are controlled remotely.